Swagatika In this post, I briefly describe the MHC genes, haplotypes, and the diversity between different MHC classes. The MHC genes Vertebrate DNA is marked with a large locus known as the major histocompatibility complex (MHC). It contains closely linked polymorphic genes that code for cell surface proteins. These cell surface proteins are known as the … Read more >>
In this article, I briefly describe the breakthrough treatments of the human immunodeficiency virus (HIV) based on the protease mechanism. The disease caused by HIV and the symptoms The human immunodeficiency virus (HIV) attacks our immune system. The acquired immunodeficiency syndrome, a chronic immune system disease, is caused by HIV. It lowers the immunity of … Read more >>
In this article, I describe types of systemic autoimmune diseases and their symptoms. What are autoimmune diseases? Autoimmune diseases happen when a person’s immune system attacks its healthy cells. Immune-stimulatory lymphocytes or antibodies recognize self-components causing cell lysis, which results in an inflammatory response in the affected organ. Autoimmune diseases may be systemic or organ-specific. … Read more >>
In this article, I briefly describe the generation of memory cells and the formation of long-lived plasma cells from B cells. Differentiation of B cells to produce memory cells B cells undergo the process of differentiation after getting activated by T cells. They differentiate to produce plasma cells, memory cells, or activated germinal center B … Read more >>
In this article, I briefly describe the response of T cells to the protozoal parasites Toxoplasma and Herpes virus. Toxoplasmosis The immune response to pathogens can be visualized in vivo by powerful imaging techniques. Toxoplasmosis is a disease caused by protozoal parasite Toxoplasma gondii, a pathogen transmitted from cats to humans through feces. It often … Read more >>
In this article, I briefly explain the response of effector and memory lymphocytes to contraction of our immune response. Factors regulating the contraction of lymphocyte In an immune response, lymphocytes can expand and increase in number up to a thousand fold. After the period of expansion, their number is suddenly decreased during the contraction period. … Read more >>
In this article, I briefly describe the pathways of several pathogens or antigens to secondary lymphoid tissue. The interaction between the lymphocytes and the antigens The pathogens and antigens perforate our barrier tissue to start an adaptive immune response by making contact with the naïve T and B lymphocytes. The naïve lymphocytes remain absent in … Read more >>
In this article, I briefly describe delayed-type hypersensitivity, which is a cell-mediated response. Hypersensitivity Our immune response gives protection to us by responding to foreign antigens. However, protecting us from foreign antigens, our immune responses can cause damage to our tissues and cells. Multiple strategies can be applied by our immune system to reduce damage … Read more >>
In this article, I briefly explain the development of B cells defined by the rearrangements of immunoglobulin genes. The development of B cell begins with the pre-pro-B cell The stages of B-cell development begin with the first cell committed to the B cell lineage, the pre-pro B cell. The developing common lymphoid progenitor gets an … Read more >>
In this article, I briefly explain the factors regulating the development of B cells. The development of immune cells Immune cells develop from immature precursors in the primary lymphoid organs, i.e., in the bone marrow and thymus. The mature antigen-specific lymphocytes first come across antigens in the secondary lymphoid organs like the spleen, lymph nodes, … Read more >>