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In this article, I briefly describe how HIV infects its host by using its coreceptors. Human immunodeficiency virus (HIV) Acquired immunodeficiency syndrome (AIDS), is a severe immunodeficiency caused by the human immunodeficiency virus (HIV). This syndrome was first recognized because of opportunistic infections in a cluster of individuals in the USA in 1981. This group … Read more >>
In this article, I briefly describe various factors causing secondary immunodeficiencies. Secondary immunodeficiencies Inherited genetic defects give rise to primary immunodeficiency whereas secondary immunodeficiency is acquired. The loss of immune function results from exposure to an external agent. These external agents include many diseases and infections, medical treatments with immunosuppressive drugs, and social conditions that … Read more >>
In this article, I briefly describe various replacement therapies that treat immunodeficiency disorders. Treatment for immunodeficiencies There are many treatment options available for immunodeficiency disorders, but no reliable treatment is available for them. Besides using antimicrobial agents or resorting to the extreme measure of complete isolation from opportunistic pathogens, immunodeficiencies can be managed through replacement … Read more >>
In this article, I briefly describe immunodeficiency disorders that disturb immune regulation, which can lead to the development of autoimmunity. Deficiencies in T-cell tolerance lead to autoimmunity The adaptive immune system recognizes and eliminates foreign antigens. It also has to recognize self-MHC proteins and suppress reactions to self-antigens in the host. The induction of tolerance … Read more >>
In this article, I briefly describe how defects in innate immune components result in diseases and deficiency. Innate immune defects Disorders in myeloid cells or in components of the complement activation pathways lead to innate immune defects. Many of these defects lead to lesser phagocytic cells or defective phagocytic processes. These processes may have defects … Read more >>
In this article, I briefly describe how primary deficiency leads to different immunodeficiency syndromes. Primary immunodeficiency Primary immunodeficiency is generally a birth defect and causes many health issues in early life. Immunodeficiency disorders are minor or life-threatening. Primary immunodeficiency diseases have provided immunologists valuable insights into the critical roles of specific proteins and cellular processes … Read more >>
In this article, I briefly describe severe combined immunodeficiency (SCID) and its interruption with T-cell and B-cell responses. Combined immunodeficiencies The diseases that result from impaired T-cell function or absence of T cells, combined with some disruption of antibody responses are known as combined immunodeficiencies. T helper cells (TH cells) are needed for complete activation … Read more >>
In this article, I briefly describe primary immunodeficiencies, which are mostly hereditary and may be minor or life-threatening. Primary immunodeficiency The condition is known as immunodeficiency when our immune system fails to protect us from diseases. Primary immunodeficiency results from an inherited genetic defect. This is generally a birth defect and causes many health issues … Read more >>
In this article, I briefly describe the methods to improve vaccine immunogenicity and enhance the immune response. Vaccines A vaccine is a biological preparation that gives immunity to some infectious diseases. The administration of vaccines is called vaccination. Edward Jenner was an English physician and scientist who pioneered the concept of vaccines including creating the … Read more >>
In this article, I briefly describe nucleic acid vaccines, their mechanism of working, and the broad and long-term immune response in humans. Nucleic acid vaccines The vaccines which use genetic material from a harmful pathogen to stimulate an immune response are called nucleic acid vaccines. These vaccines can contain either DNA or RNA. This genetic … Read more >>