Costimulatory receptors for activation of T cells

In this article, I briefly describe costimulatory receptors CD28 and ICOS and how they bind with their ligands. Costimulatory receptors Co-stimulatory signals are required for optimal T-cell activation. T-cell non-responsiveness arises from high affinity TCR-MHC interactions in the absence of functional antigen presenting cells (APCs). It is called T cell anergy. The interaction between specific … Read more >>